Women have higher rate of complications but lower mortality after undergoing TAVR: Study

In comparison to men, women face higher incidence of complications after undergoing transcatheter aortic valve replacement (TAVR) procedures. However, even after complications, women have lower long-term mortality rates in comparison with men.

After a year of undergoing TAVR, women were having 28% more chance of survival than men and 18% less likely to be re-hospitalized irrespective of the fact that during the 30 days after the surgery, women were having higher rates of vascular complication and major bleeding.

One of the reasons that women are having better survival rate after undergoing TAVR procedures could be women may be having greater myocardial adaption to AS. “Women more often develop concentric myocardial hypertrophy with less fibrosis compared with men, and these changes reverse more rapidly after valve repair”, affirmed the study researchers.

Study researchers Nina Johnston and Christina Christersson from Uppsala University in Sweden said that the study highlights the importance of sex-specific analysis of patient selection, intervention method and evaluation of procedural risk in improving long-term follow-up in high-risk patients AS and undergoing TAVR.

A second analysis was also carried out in which researchers looked at the sex-specific differences among the 1,220 women and 1,339 men who underwent the TAVR procedure. The patients were from 25 hospitals across the US, Canada and Germany.

In comparison with men, women were having higher Society of Thoracic Surgeons Predicted Risk of Mortality scores- 11% versus 12%. The difference was found irrespective of the fact that they were having lower rates of coronary heart disease, less frequent peripheral vascular disease, fewer prior permanent pacemakers and coronary artery bypass grafts.

Women were also found to have smaller aortic valve areas. After undergoing the TAVR, the women in the group witnessed more vascular complications. The complications included thoracic aortic dissection, need for blood transfusion and in severe cases, death.

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